| Does
gamma-hexachlorocyclohexane (lindane) increase the rapid delayed outward K+
current (IKr) in frog atrial myocytes? Martin-Pierre Sauviat  ,
Anthony Colas
and Nicole Pages BMC Pharmacology 2002 2: 15 Abstract (provisional)
Background The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage-clamp technique. Results Lindane (0.34 microM to 6.8 microM) dose-dependently shortened the action potential duration. Under voltage-clamp conditions, lindane (1.7 microM) increased the amplitude of the outward current (Iout) which developed in Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM) and TEA (1 mM). The lindane-increased Iout was not sensitive to Sr2+ (5 mM). It was blocked by subsequent addition of quinidine (0.5 mM) or E 40-31 (1 microM). Conclusion In conclusion,our data revealed that lindane increased the rapid delayed outward potassium current which contributed to the AP repolarization of cardiac muscle. http://www.biomedcentral.com/1471-2210/2/15/abstract
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