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Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice.

AUTHOR: Trivedi NP, Rawal UM
TITLE: Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice.
SOURCE: Indian J Exp Biol; 39(1):41-6 2001   UI: 21247932
ABSTRACT: Andrographis paniculata (AP) treatment prevents BHC induced increase in the activities of enzymes y-Glutamyl transpeptidase, glutathione-S-transferase and lipid peroxidation. The activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and the levels of glutathione were decreased following BHC effect. Administration of AP showed protective effects in the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase as well the level of glutathione. The activity of lipid peroxidase was also decreased. The result indicate antioxidant and hepatoprotective action of A. paniculata.
MESH TERMS: Animal
Antioxidants/*Pharmacology
Hepatitis, Toxic/Enzymology/Metabolism/*Prevention and Control
Lindane/*Toxicity
Lipid Peroxidation/Drug Effects
Liver/*Drug Effects
Liver Neoplasms, Experimental/Chemically Induced/Enzymology/Metabolism/*Prevention and Control
Male
Mice
Plant Extracts/*Pharmacology
Plants, Medicinal/*Chemistry
LANGUAGE: ENG
PUBLICATION TYPE: JOURNAL ARTICLE
TITLE ABBREVIATION: Indian J Exp Biol
YEAR: 2001
ADDRESS: Zoology Department, Gujarat University, Ahmedabad 380009, India.
ENTRY MONTH: 200105
CAS NO.: 0 (Antioxidants)
0 (Plant Extracts)
58-89-9 (Lindane)
 

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